Micropuncture study of concentration and fate of albumin in rat nephron.

نویسندگان

  • P D Leber
  • D J Marsh
چکیده

LEBER, PAUL II., AND DONALD J. MARSH. Micropuncture study of concentration and fate of albumin in rat nephron. Am. J. Physiol. !219(2) : 358-363. 1970.-Albumin concentration in various segments of the rat nephron was determined by analyzing freeflow micropuncture samples with a radioimmunoassay. The average proximal tubular fluid concentration was 3.3 mg/lOO ml but fluctuated over several milligrams, probably reflecting heterogeneity in glomeru lar permeabili tY or tubular reabsorption or both. The heterogeneity was sufficient to preclude the use of an albuminversus-inulin TF/P regression to determine whether there is albumin reabsorption in the proximal tubule. Variation in albumin concentration was also present in the distal tubule, but the average concentration increase between the proximal and distal tubule can be explained by assuming no protein transport occurred in the intervening segments of the nephron. Finally, the data suggest that protein may be reabsorbed in the collecting ducts. Several inconsistencies in current views about protein reabsorption by pinocytosis are discussed in light of the micropuncture data.

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عنوان ژورنال:
  • The American journal of physiology

دوره 219 2  شماره 

صفحات  -

تاریخ انتشار 1970